Stereochemistry of Organic Compounds by Eliel: A Comprehensive and Authoritative Textbook on 3D Chemistry
Stereochemistry of Organic Compounds Eliel PDF Free Downloadgolkes
Introduction
Stereochemistry is one of the most fascinating and important aspects of organic chemistry. It deals with the three-dimensional structure and spatial arrangement of molecules, which can have a profound impact on their physical, chemical and biological properties. Stereochemistry is essential for understanding the structure, function and synthesis of natural products, pharmaceuticals, polymers and materials.
stereochemistry of organic compounds eliel pdf free downloadgolkes
One of the pioneers and leading authorities in stereochemistry was Ernest L. Eliel (1921-2008), a German-American chemist who made significant contributions to the field. He was a professor at several universities, including the University of North Carolina at Chapel Hill, where he spent most of his career. He was also a prolific author who wrote several books and articles on stereochemistry and related topics.
One of his most influential works was Stereochemistry of Organic Compounds, a comprehensive textbook that covers both the basic principles and practical aspects of stereochemistry as applied to organic compounds. The book was first published in 1994 by Wiley-Interscience, with Samuel H. Wilen and Lewis N. Mander as co-authors. The book has been widely used by students and researchers of organic chemistry as a valuable source of information and inspiration.
Stereochemistry: Definition and Concepts
Stereochemistry is the branch of chemistry that studies the spatial arrangement of atoms in molecules. It differs from constitution, which refers to the type and number of atoms in a molecule, and configuration, which refers to the connectivity or order of atoms in a molecule. Stereochemistry focuses on how atoms are oriented in space relative to each other.
Molecules that have the same constitution and configuration but differ in their spatial arrangement are called stereoisomers. Stereoisomers can have different physical, chemical and biological properties due to their different interactions with other molecules or external stimuli. For example, some stereoisomers can rotate plane-polarized light in different directions or have different smells or tastes.
The most common types of stereoisomers are enantiomers and diastereomers. Enantiomers are mirror images of each other that cannot be superimposed. They have identical physical properties except for their optical activity. Diastereomers are not mirror images of each other and can have different physical properties. A molecule that has two or more stereocenters (atoms that are bonded to four different groups) can have multiple stereoisomers.
A molecule that has a non-superimposable mirror image is called chiral. A molecule that is superimposable on its mirror image is called achiral. Chirality is a property that depends on both the molecule and its environment. A molecule that is chiral in one environment may become achiral in another environment due to symmetry or conformational changes.
A special type of achiral molecule is a meso compound, which has two or more stereocenters but has an internal plane of symmetry that makes it superimposable on its mirror image. A mixture that contains equal amounts of enantiomers is called a racemic mixture or a racemate. A racemic mixture has no net optical activity because the effects of each enantiomer cancel out.
The methods for determining and assigning absolute and relative configurations of stereoisomers include spectroscopic techniques (such as NMR, IR, UV-vis, CD), crystallographic techniques (such as X-ray diffraction), chemical methods (such as stereospecific reactions or derivatization) and computational methods (such as molecular modeling or quantum calculations).
Stereochemistry: Applications and Examples
Stereochemistry has many applications and examples in various fields of organic chemistry. Some of them are:
Physical properties: Stereoisomers can have different melting points, boiling points, solubilities, densities, refractive indices, dipole moments or specific rotations due to their different intermolecular forces or interactions with polarized light.
Chemical properties: Stereoisomers can have different reactivities, rates or mechanisms due to their different steric or electronic effects or orientations relative to other molecules or reagents.
Biological properties: Stereoisomers can have different biological activities, functions or effects due to their different interactions with enzymes, receptors or biomolecules.
Natural products: Many natural products such as amino acids, sugars, terpenes, alkaloids or steroids have complex stereochemical structures that determine their biological roles or functions.
Pharmaceuticals: Many drugs such as ibuprofen, thalidomide, penicillin or morphine have stereochemical features that affect their pharmacological actions or side effects.
Polymers: Many polymers such as polypropylene, nylon or polylactic acid have stereochemical variations that affect their physical properties such as strength, flexibility or biodegradability.
Materials: Many materials such as liquid crystals, chiral catalysts or chiral sensors have stereochemical properties that affect their optical, electrical or magnetic properties.
Stereochemistry of Organic Compounds by Eliel: Overview and Features
Stereochemistry of Organic Compounds by Eliel is a comprehensive textbook that covers both the basic principles and practical aspects of stereochemistry as applied to organic compounds. The book was first published in 1994 by Wiley-Interscience, with Samuel H. Wilen (City College of New York) and Lewis N. Mander (Australian National University) as co-authors.
The book consists of 24 chapters that cover various topics such as structure, stereoisomers, symmetry, configuration, properties, separation, heterotopic ligands, alkenes, conformation, cyclic molecules, stereoselective synthesis, chiroptical properties, chirality without chiral centers, and more.
The book also includes over 1000 illustrations, numerous tables, over 2500 references, a glossary, and an index.
The book has several features and benefits for students and researchers of organic chemistry such as:
Comprehensive: The book covers all aspects of stereochemistry from theory to practice, from fundamentals to applications, from simple to complex systems.
Rigorous: The book provides a thorough, organized, and logical treatment of stereochemistry with rigorous definitions, explanations, and proofs.
Up-to-date: The book reflects the latest developments and advances in stereo chemistry and the latest references and examples.
Clear: The book uses a clear, concise and consistent style of writing and presentation, with over 1000 illustrations and chemical structures, numerous tables and a glossary to aid understanding and learning.
Authoritative: The book is written by Ernest L. Eliel, one of the pioneers and leading authorities in stereochemistry, with Samuel H. Wilen and Lewis N. Mander as co-authors, who are also experts in the field.
Stereochemistry of Organic Compounds by Eliel: PDF Free Downloadgolkes
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Conclusion
Stereochemistry is a fascinating and important aspect of organic chemistry that deals with the three-dimensional structure and spatial arrangement of molecules. It affects their physical, chemical and biological properties and influences their synthesis, separation and analysis. Stereochemistry is essential for understanding and designing natural products, pharmaceuticals, polymers and materials.
Stereochemistry of Organic Compounds by Eliel is a comprehensive textbook that covers both the basic principles and practical aspects of stereochemistry as applied to organic compounds. The book was written by Ernest L. Eliel, one of the pioneers and leading authorities in stereochemistry, with Samuel H. Wilen and Lewis N. Mander as co-authors. The book provides a thorough, organized, up-to-date, clear and authoritative treatment of stereochemistry with over 1000 illustrations, numerous tables, over 2500 references and a glossary.
If you are interested in learning more about stereochemistry or getting a copy of Eliel's book, you can visit the Wiley website (https://www.wiley.com/en-us/Stereochemistry+of+Organic+Compounds-p-9780471016700) or Amazon (https://www.amazon.com/Stereochemistry-Organic-Compounds-Ernest-Eliel/dp/0471016705). Alternatively, you can try to download the PDF version of the book for free using downloadgolkes (https://downloadgolkes.com/), but be aware of the legal, ethical, risky, incomplete and poor quality issues that may arise from doing so.
FAQs
Here are some frequently asked questions about stereochemistry or Eliel's book with brief answers:
Question
Answer
What is the difference between R/S and E/Z notation?
R/S notation is used to assign absolute configurations to chiral centers based on their priority order according to Cahn-Ingold-Prelog rules. E/Z notation is used to assign relative configurations to alkenes based on their priority order according to Cahn-Ingold-Prelog rules.
What is conformational analysis?
Conformational analysis is the study of how molecules can change their shape by rotating around single bonds. It involves determining the possible conformations, their energies, their interconversions and their effects on reactivity.
What are stereoselective and stereospecific reactions?
Stereoselective reactions are reactions that produce one stereoisomer preferentially over another from a mixture of stereoisomers. Stereospecific reactions are reactions that produce one stereoisomer exclusively from one stereoisomer.
What are chiral auxiliaries and chiral catalysts?
Chiral auxiliaries are chiral compounds that are temporarily attached to a substrate to control its stereochemistry during a reaction. Chiral catalysts are chiral compounds that accelerate a reaction without being consumed and influence its stereochemistry by interacting with the substrate or intermediate.
What are circular dichroism (CD) and optical rotatory dispersion (ORD)?
Circular dichroism (CD) is a spectroscopic technique that measures the difference in absorption of left- and right-circularly polarized light by a chiral molecule. Optical rotatory dispersion (ORD) is a spectroscopic technique that measures the variation of optical rotation of plane-polarized light by a chiral molecule as a function of wavelength.